Selected Publications

1. Sui GC, Soohoo C, Affar EB, Shi YJ, Forrester W, Shi Y. (2002) A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA. Vol 99:5515-20.

2. Shi, YJ., Sawada, J-I., Sui, G.C., Affar, E.B., Whetstine, J., Lan, F., Ogawa, H., Luke, M.,P-S., Nakatani, Y., and Shi, Y. (2003). Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature, Vol 422:735-8.

3. Shi, YJ., Lan, F., Matson, C., Mulligan, P., Whetstine, JR., Cole, PA., Casero, RA. and Shi, Y. (2004). Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell, Vol 119:941-953.

4. Whetstine, JR., Nottke, A., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G.,Colaiacovo, M., and Shi, Y. (2006). Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell, Vol 125:467-481.

5. Lan, F*., Collins, R*., De Cegli, R., Alpatov, R., Horton, J.R., Shi, XB, Gozani, R., Cheng, XD+, and Shi, Y+. (2007). Recognition of unmethylated H3K4 links BHC80 to LSD1 mediated gene repression. Nature, Vol 448:718-723. *co-first; +co-corresponding

6. Lan, F., Bayliss, PE#., Rinn, J#., Whetstine JR#., Wang JK., Chen, SZ., Iwase, S., Roberts, TM., Chang, HY., and Shi, Y. (2007). A histone H3 lysine 27 demethylase regulates animal posterior development. Nature, Vol 449:689-94. #Co-second authorship.

7. Qi, HH*, Sarkissian, M*., Hu, GQ., Wang Z., Bhattacharjee, A., Gordon, DB., Gonzales, M., Lan, F., Ongushaha, PP., Huarte, M., Yaghi, NK., Lim, S., Garcia B., Brizuela, L., Zhao, KJ., Roberts, TM, and Shi, Y. (2010). Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature, Vol 466:503-7. *co-first.

8. Alpatov R, Lesch, B.J., Nakamoto-Kinoshita M, Blanco, A, Chen, SZ., Stuetzer A, Armache K, Simon MD, Muzaffar, A, Murn, J., Prisic, S., Kutateladze, TG., Vakoc CR, Kingston RE, Fischle W, Warren ST., Page, D.C. and Shi Y. (2014) A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell, Vol 157 (4):p869–881.

9. Xiang, Y*., Laurent, B*., Hsu, C-H*., Nachtergaele, S., Lu, ZK., Xu, CY., Sheng, WQ., Jian, OY., Wang, SQ., Ling, D., Hsu, H. Zou, L., Jambhekar, A., He, C., and Shi, Y. (2017). m6A RNA methylation regulates the UV-induced DNA damage response. Nature, Vol 543(7646): 573-576. *Equal contributions.

10. Sheng, W.Q.*, LaFleur, M.W.*, Nguyen, T.H., Chen, S.J., Chakravarthy, A., Conway, J.R., Li, Y., Chen.,Yang, H., Hsu, P-H., Van Allen, E.M., Freeman, G.J., De Carvalho, D.D., He, H.H.H., Sharpe, A.H.+,and Shi, Y+, (2018). LSD1 ablation in tumor cells simulates anti-tumor immunity and enables checkpoint blockade. Cell. Vol 174(3): 549-63. Epub, 06/21/2018. *Co-first; +Co-corresponding