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The long term goal of this research is to develop chromatin-based therapies for brain tumors in children. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1580137437808-FHT2ZT2IJBM8IYTQ3W7S/Anastas_Jamie.jpg Team Gallery - Jamie Anastas, PhD Jamie.Anastas@childrens.harvard.edu BS, Cornell University PhD, University of Washington My current projects are focused on trying to understand epigenetic mechanisms driving tumorigenesis in pediatric high grade gliomas harboring histone mutations. The long term goal of this research is to develop chromatin-based therapies for brain tumors in children. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551553114897-P35KF8LOQ2SEJ2A0LP7V/Dhall_Abhinav.jpg Team Gallery - Abhinav Dhall, PhD abhinav.dhall@gmail.com Integrated BSc. And Masters in Chemistry, IIT-Bombay, India / Ph.D. Chemistry, University of Washington, Seattle Abhinav is interested in understanding the epigenetic basis of differentiation, especially the role played by histone methylation in the differentiation blockade observed in AML. I am also working toward a Certified Personal Trainer certification from ASCM. https://static1.squarespace.com/static/5bb62b0c9b7d1558a71469fc/5c3bb438352f53368c064427/5c3bb4484ae237c2465142ff/1765219855367/ Team Gallery https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551553166443-CTHTRKKGHRQ2BCLQ51QU/Erdem.jpg Team Gallery - Erdem Sendinc, PhD Erdem.Sendinc@childrens.harvard.edu BS, Molecular Biology and Genetics at Middle East Technical University, Turkey / PhD, Biochemistry and Molecular Genetics, University of Virginia Dr. Sendinc is interested in epitranscriptomics and mechanisms by which epigenetic information is inherited over the generations in C. elegans. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551548000306-86VPSJPJ7AH68XCLS40M/Fiseha_Kebede_Adam-597.jpeg Team Gallery - Adam Fiseha-Kebede, PhD adam.kebede@childrens.harvard.edu BSc., Jacobs University Bremen, Germany / MSc., Jacobs University Bremen, Germany / Ph.D, University of Freiburg, Germany I'm interested in how nucleic acid modifications regulate gene expression and how that is altered in disease. I enjoy playing and watching soccer. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551548004870-B41U058EQP47YH86RCWY/Gu_Lei.jpg Team Gallery - Lei Gu, PhD Lei.Gu@childrens.harvard.edu BS, China / MS and PhD, Germany I am interested in long range epigenetic regulations in cancer and transgenerational epigentic inheritance. Hobby: Soccer https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551548069555-IM9JFUFUZDMYZE1T0U4L/Jiao_Alan-131.jpg Team Gallery - Alan Jiao, PhD alanlongjiao@gmail.com BSc: Immunology, University of Toronto, Canada / PhD: Molecular Cellular Developmental Biology, Yale University, USA Many cancer cells exist in highly abnormal epigenetic states. I am broadly interested in better understanding those states in order to identify cancer-specific vulnerabilities. I am also a model organism enthusiast. My current projects include investigating the role of certain histone mutations in driving a rare, incurable childhood brain cancer. I am studying these mutations in systems ranging from primary human tumors to roundworms (C. elegans). I love poker, badminton, basketball, snowboarding, and cooking, none of which I am particularly good at. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633631636969-KS3XBKDQFOF0WBXOOFXL/photo%252B%2525281%252529.jpg Team Gallery - Violetta Karwacki Neisius, MD, PhD Contact: violkn@gmail.com MD, Medical School Hannover, Germany / PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, UK Dr. Karwacki-Neisius is studying X linked intellectual disability. She will use iPS cells containing mutations in the histone demethylase KDM5C together with isogenic control cell lines to define mechanisms underlying intellectual disability. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1553913392317-SE4QPZ5O21L5NUKALD3P/Sheng_Wanqiang.jpg Team Gallery - Wanqiang Sheng, PhD Wanqiang.Sheng@childrens.harvard.edu BSc, Ocean University of China / PhD, National University of Singapore I am interested in understanding the complex interaction between tumor and host imune system in tumorigenesis and tumor development, and particularily its regulation by epigenetic and chromatin mechansim. I am also interested in characterizing epigenetic/chromatin factors that can be targeted for enhancing anti-tumor immunity and immunotherapy. I enjoy travelling and watching movies https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551548105005-HJWL24XWK8Z3NQC7WU88/Yi+Liu.png Team Gallery - Yi Liu, PhD Yi.Liu@childrens.harvard.edu BS Wuhan University, PhD Cornell University I am investigating the molecular mechanisms of how chromatin factors can modulate anti-tumor immunity, which would lead to the discovery of new potential therapeutic targets for cancer treatment. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1551548125854-OM9X08EFQQOY659EAUHS/Zee_Barry-235.jpg Team Gallery - Barry Zee, PhD b.m.zee1@gmail.com B.A. Swarthmore College, PA / Ph.D. Princeton University, NJ Research Interest: Role of LSD1 in AML differentiation blockade Hobby: Custards https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1562953607315-VIZTFE9OV8RVOKH3DQV7/image002.jpg Team Gallery - Zhennan Shi, PhD Zhennan.Shi@childrens.harvard.edu B.S. Northwest A&F University, China / Ph.D. Fudan University, China I am interested in investigating the interplay between cellular metabolism and epigenetic regulation in different physiological and pathological processes, such as aging and cancer. I enjoy hiking and swimming. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1563825910673-IUPADLSBCGW2LGHUF9YH/Saddiq_Habiballah-12360.jpg Team Gallery - Habib Shojaei, DVM, PhD Habiballah.Shojaeisaadi@childrens.harvard.edu DVM., Urmia University, Iran / MSc., University of Calgary, AB, Canada / PhD., Université Laval, QC, Canada Dr. Shojaei is interested in epigenetics studies, and in particular histone modifications in early development. He is studying the role of chromatin histone demethylase KDM5C, in early (neuro)development as well as male and female reproductive biology. He enjoys watching movies, listening to music, and learning and working with R programming. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1564426848162-RST0VFBEU9F9R3423BM3/Chakraborty_Damayanti-13474_web2.jpg Team Gallery - Damayanti Chakraborty, PhD Damayanti.Chakraborty@childrens.harvard.edu BSc. Presidency College, Calcutta, India/ MSc. Calcutta University, Calcutta, India/ PhD. University of Kansas Medical Center, Kansas City, USA. I am interested in epigenetic regulation of cell fate changes in early development and diseases. I am an avid fan of independent films, love to travel and explore different cultures through food, different cooking styles and techniques. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633519150329-0PI7CHFDEF516QQOT0LU/Sudipta.jpg Team Gallery - Sudipta Ghosh, PhD Contact: sudipta.ghosh@ludwig.ox.ac.uk B.Sc. UBKV, India/ M.Sc. UASD, India/ Ph.D. IIT Guwahati, India I'm interested in RNA and it's interacting proteins (especially splicing factors, RNA modifying enzymes) which are involved in gene regulation and disease progression. I enjoy playing squash and do painting occasionally. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1637866950338-MLSEADUBPVQV7ND5N5A4/Yuanqin+Yang_photo.jpg Team Gallery - Yuanqin Yang, PhD Contact: yuanqin.yang@ludwig.ox.ac.uk B.Sc. and M.Sc. Zhejiang Sci-tech University/ Ph.D Shanghai Jiao Tong University I am interested in epigenetic and epitranscriptomic regulators of cancer immunology and immune aging. I am an NBA fan and enjoy running. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1642527073865-1VVAUCJPY6BHCXQDDRVU/photo_2022-01-18_12-20-10.jpg Team Gallery - Amir Hosseini, PhD Contact: amir.hosseini@ludwig.ox.ac.uk I received my PhD degree in System Medicine (Molecular Oncology) at European Institute of Oncology (IEO)/University of Milan. In 2020 I joined Dr. Daniel De Carvalho’s lab at Princess Margaret Cancer Centre in Toronto to pursue my postdoctoral study. I’m interested in how epigenetics and RNA modifications affect cancer development, progression and drug response. I enjoy watching football and doing workout occasionally. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1642788391644-KX7F7I4HJR54TWLHBY2T/Image+%281%29.jpeg Team Gallery - Hui Huang, PhD Contact: hui.huang@ludwig.ox.ac.uk https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1648124223657-G2N9Z6JYL5VIG997BPEW/Berna_BouTayeh.png Team Gallery - Berna Bou Tayeh, PhD Research Interests The use of immune checkpoint blockade strategies, anti-PD1 and anti-CTLA-4, to reverse T cell exhaustion and improve their cytotoxic potential has revolutionized the treatment of cancer. Other immune cells playing an important role in the defense against cancer can also undergo exhaustion under specific conditions. However, little is known about the mechanisms underlying this phenomenon and the ways to reverse it. The aim of my research is to unveil key epigenetic regulators implicated in the exhaustion of cytotoxic innate immune cells, Natural Killer cells. This work will improve our understanding of NK cell dysfunction. Moreover, we hope to be able to discover regulators that can be targeted for NK-cell based anti-cancer therapy. Background I completed my BSc in Biological Sciences at the Lebanese University and my masters and PhD degrees at Aix-Marseille University, France. During my PhD, I studied the mechanisms of Natural Killer cell alterations in Acute Myeloid Leukemia. Then I worked as a Postdoctoral Research Associate at the University of Cambridge to deepen my understanding of the interaction between immune cells and other components of the tumor microenvironment. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1686752181438-YFFV3U92ARHAW10NU0LX/12022022-_DSC1310+copie.jpeg Team Gallery - Sylvain Nguyen, PhD https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1689266359262-HYR59YU4GU9ZDSY98WAQ/IMG_2974+%281%29.png Team Gallery - Sheenagh Aiken, PhD https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1708950155103-BNH74EZRPH2VDJXWAMT7/Foto+Ines.png Team Gallery - Ines Kaltheuner, PhD Postdoc at the Ludwig Institute of Cancer Research, Oxford University Education: BSc, University of Hamburg, Germany; MSc and PhD, University of Bonn, Germany Research focus: I am interested in the functions and molecular mechanisms of transcriptional regulators, such as chromatin and RNA modifying enzymes https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1708950206464-J0H2ITWZD1TNTKWJNMHS/qianpeng.li.jpg Team Gallery - Qianpeng Li, PhD Research interest: Transposable elements (TEs) are mobile DNA sequences that are widespread in the human genome. Although most TEs lost their ability to “jump” in the genome, they have been found to play important roles in gene regulation and human cancer. I’m interested in investigating the epigenetic regulators governing the transcriptional activity of TEs and their roles in cancer therapy. Background: I obtained my BS in Biomedical Engineering from Beijing University of Aeronautics and Astronautics in 2016. Following that, I pursued my PhD in Bioinformatics at the Beijing Institute of Genomics. During my doctoral studies, I investigated the impact of transposon elements on the expression regulation of long non-coding RNAs, exploring their significance in cell identity and developmental processes. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1745825782373-CGCAIINXTDWQL5K3E1KS/IMG_2838.JPG Team Gallery - Niklas Grassl, MSc, MD Contact: niklas.grassl@ludwig.ox.ac.uk M.Sc. physics and MD Ludwig Maximilian University of Munich, Germany / Residency in Neurology Medical Faculty Mannheim, Heidelberg University Research Focus Brain tumors are among the most aggressive and difficult-to-treat cancers in humans. I’m interested in understanding how these tumors arise from precursor cells and how epigenetic dysregulation contributes to their resistance to therapy. By uncovering these mechanisms, I hope to help pave the way toward more effective treatment options for patients. About Me Outside the lab, I enjoy ski touring, traveling, and exploring philosophy and history. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1765219807660-8LDIFR1BD2KSI7ZOZ5F1/42ee593ac0afe273cd86284149a7454a.webp Team Gallery - Chiara Grelloni, PhD https://www.harvardshilab.org/workouts daily 1.0 2024-05-25 https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1540346873644-2R3MLB6X3EWLTRUO5SXW/white.png Home https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1544298014220-N1UZMGT346T573BHUGT7/background_v7.png Home https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1592334514834-I5G3U96PHHFF32X4JY7W/gold%281%29.png Home https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/4b9db3c5-359d-446c-b1f4-17001ee385b6/Presentation+4.jpg Home https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1594841612361-WRJSZBXPOJPG5VAML482/oxford_brand_cmyk_pos.jpg Home https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1623269392803-VH07EYXNI8DFGZOOGQVB/Ludwig+Oxford+RGB.jpg Home https://www.harvardshilab.org/grad-student-gallery daily 0.75 2025-04-28 https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1583784308483-SJ9NED3JKXXRDK0YFDMR/image-asset.jpeg Grad Student Gallery - Michael Costello Visiting PhD student from University of California-Santa Barabra Michael is interested in the post-transcriptional determinants of stress responses, particularly those which influence the translation of select mRNAs. Email: Michael.Costello2@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1583784308483-SJ9NED3JKXXRDK0YFDMR/image-asset.jpeg Grad Student Gallery - Michael Costello Visiting PhD student from University of California-Santa Barabra Michael is interested in the post-transcriptional determinants of stress responses, particularly those which influence the translation of select mRNAs. Email: Michael.Costello2@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1595256565916-2TUZXQMSG81136LR8OFP/Chen+Zhou.jpg Grad Student Gallery - Chen Zhou Graduate student at Harvard BBS program Education background: BS, Tsinghua University Research focus: I am interested in the mechanisms of gene expression regulation in response to environmental changes, especially those mediated by epigenetic modifications. Contact: Chen.Zhou@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633441713776-P349NRUN7YASQH7OB1FW/MHarrisOxCardPhoto+%282%29.jpg Grad Student Gallery - Matthew Harris Contact: matthew.harris2@keble.ox.ac.uk Graduate student in the Chemistry in Cells program Education background: MSci, University of Cambridge with Professor David Spring Research focus: Under the supervision of Profs Yang Shi, Chris Schofield and Peter McHugh I am investigating the chemistry, enzymology and cellular biology of the newly discovered m6A modifying enzymes. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633708034631-EAHYAO6BWNRWJWZOPRML/FW_Headshot.jpeg Grad Student Gallery - Felice Wallner Contact: felice.wallner@stcatz.ox.ac.uk Education: Bsc at the University of Applied Sciences in Krems, Austria Interests: Hiking, cooking, board games, gymnastics, cello https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1634044936158-QSMU2AJ3TKHYZIN7J9UZ/Image.jpeg Grad Student Gallery - Yunyi Wang Contact: yunyi.wang@st-hughs.ox.ac.uk https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1698415206426-7402SDNA95V4K5NS2MQC/%5BYuhua%2C+LIM%5D+Profile+picture+for+Shi+lab+website.jpg Grad Student Gallery - Yuhua Lim Contact: yuhua.lim@lmh.ox.ac.uk Education background: BA (Hons) and MSci (with a specialisation in biochemistry for both degrees) at the University of Cambridge Research focus: I am interested in understanding the contribution of DNA/RNA-modifying enzymes to the immune system, particularly in how targeting these factors could potentially synergise with existing cancer immunotherapies. Interests outside of the lab: Badminton, cooking, painting/sketching, piano, and poetry https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1699971730881-J3H5FM644OIVWL5VS9AS/Cherubin+%28002%29.jpeg Grad Student Gallery - Cherubin Manokaran Contact: cherubin.manokaran@st-annes.ox.ac.uk Research focus: Cherubin is interested in understanding the epigenetic mechanisms that can drive cancer cell plasticity using models of pediatric brain cancer. https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1745825565642-XFI25AEUPSC4QH00YEUS/Chenyu+Jiang+Pic.jpeg Grad Student Gallery - Chenyu Jiang https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1745825697854-TI4LWKNZJZ47DK83O0H2/headshot.jpg Grad Student Gallery - Chunrun Qu https://www.harvardshilab.org/research-assistants daily 0.75 2023-06-19 https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633703562121-SPLHJATI3T157U0O75AP/Faria_photo_shilab.jpg Research Assistants - Faria Afreen Contact: faria.afreen@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633703562121-SPLHJATI3T157U0O75AP/Faria_photo_shilab.jpg Research Assistants - Faria Afreen Contact: faria.afreen@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1634045913249-U6P378XDW0IRNDU2VJCO/image.jpg Research Assistants https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1634045356614-OH7PLXXCU21LHDX86N6N/Faria_photo_shilab.jpg Research Assistants - Faria Afreen Contact: faria.afreen@childrens.harvard.edu https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1633704467672-I0IPVUASXQBY8M0O7CS0/Faria_photo_shilab.jpg Research Assistants - Faria Afreen Contact: faria.afreen@childrens.harvard.edu https://www.harvardshilab.org/lab-gallery daily 0.75 2026-03-11 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https://www.harvardshilab.org/alumni daily 0.75 2023-05-30 https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/1592333706084-E9SUQVIN2MI92Z5D0LHN/black_fade%281%29.png Alumni https://images.squarespace-cdn.com/content/v1/5bb62b0c9b7d1558a71469fc/6633d01b-be5e-43ce-9b90-1c6722b6192b/radcliffe-camera-aerial.jpeg Alumni - Lab Alumni https://www.harvardshilab.org/new-page daily 0.75 2021-10-08 https://www.harvardshilab.org/selected-publication-1 daily 0.75 2024-12-03 https://www.harvardshilab.org/review-articles daily 0.75 2024-12-03